Package: drugdevelopR 1.0.1

Lukas D. Sauer

drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Plan optimal sample size allocation and go/no-go decision rules for phase II/III drug development programs with time-to-event, binary or normally distributed endpoints when assuming fixed treatment effects or a prior distribution for the treatment effect, using methods from Kirchner et al. (2016) <doi:10.1002/sim.6624> and Preussler (2020). Optimal is in the sense of maximal expected utility, where the utility is a function taking into account the expected cost and benefit of the program. It is possible to extend to more complex settings with bias correction (Preussler S et al. (2020) <doi:10.1186/s12874-020-01093-w>), multiple phase III trials (Preussler et al. (2019) <doi:10.1002/bimj.201700241>), multi-arm trials (Preussler et al. (2019) <doi:10.1080/19466315.2019.1702092>), and multiple endpoints (Kieser et al. (2018) <doi:10.1002/pst.1861>).

Authors:Stella Erdmann [aut], Johannes Cepicka [aut], Marietta Kirchner [aut], Meinhard Kieser [aut], Lukas D. Sauer [aut, cre]

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Bug tracker:https://github.com/sterniii3/drugdevelopr/issues

On CRAN:

120 exports 3 stars 1.70 score 15 dependencies 15 scripts 173 downloads

Last updated 8 months agofrom:807bc3a33f. Checks:OK: 7. Indexed: yes.

Exports:d3_skipII_ttedbivanormdrugdevelopRdrugdevelopResultEd3_LEd3_L2Ed3_REd3_R2Ed3_tteEn3_binary_LEn3_binary_L2En3_binary_REn3_binary_R2En3_normal_LEn3_normal_L2En3_normal_REn3_normal_R2Epgo_binary_L2Epgo_binary_R2Epgo_L2Epgo_normal_L2Epgo_normal_R2Epgo_R2Epgo_tteEpgo23Epgo23_binaryEpgo23_normalEPsProg_binary_LEPsProg_binary_L2EPsProg_binary_REPsProg_binary_R2EPsProg_LEPsProg_L2EPsProg_multiple_normalEPsProg_multiple_tteEPsProg_normal_LEPsProg_normal_L2EPsProg_normal_REPsProg_normal_R2EPsProg_REPsProg_R2EPsProg_tteEPsProg2EPsProg2_binaryEPsProg2_normalEPsProg23EPsProg23_binaryEPsProg23_normalEPsProg3EPsProg3_binaryEPsProg3_normalEPsProg4EPsProg4_binaryEPsProg4_normalEss_binaryEss_multiple_normalEss_multiple_tteEss_normalEss_ttefmaxfminoptimal_biasoptimal_bias_binaryoptimal_bias_normaloptimal_binaryoptimal_multiarmoptimal_multiarm_binaryoptimal_multiarm_normaloptimal_multiple_normaloptimal_multiple_tteoptimal_multitrialoptimal_multitrial_binaryoptimal_multitrial_normaloptimal_normaloptimal_tteos_ttepgo_binarypgo_multiple_normalpgo_multiple_ttepgo_normalpgo_tteposp_normalprior_ttePsProg_binaryPsProg_normalPsProg_ttepwss_binaryss_normalss_tteutility_binary_Lutility_binary_L2utility_binary_Rutility_binary_R2utility_Lutility_L2utility_multiarmutility_multiarm_binaryutility_multiarm_normalutility_multiple_normalutility_multiple_tteutility_normal_Lutility_normal_L2utility_normal_Rutility_normal_R2utility_Rutility_R2utility_tteutility2utility2_binaryutility2_normalutility23utility23_binaryutility23_normalutility3utility3_binaryutility3_normalutility4utility4_binaryutility4_normal

Dependencies:codetoolscubaturedigestdoParallelexpmforeachiteratorslatticeMASSMatrixmsmmvtnormprogressrRcppsurvival