Package: drugdevelopR
Type: Package
Title: Utility-Based Optimal Phase II/III Drug Development Planning
Version: 1.0.2
Authors@R: c(person("Stella", "Erdmann",
                    email = "erdmann@imbi.uni-heidelberg.de", role = "aut"),
             person("Johannes", "Cepicka", role = "aut"),
             person("Marietta", "Kirchner", role = "aut"),
             person("Meinhard", "Kieser", role = "aut"),
             person("Lukas D.", "Sauer", email = "sauer@imbi.uni-heidelberg.de",
                    role = c("aut", "cre"),
                    comment = c(ORCID = "0000-0002-1340-9994")))
Author: Stella Erdmann [aut], Johannes Cepicka [aut], Marietta Kirchner
        [aut], Meinhard Kieser [aut], Lukas D. Sauer [aut, cre]
        (<https://orcid.org/0000-0002-1340-9994>)
Maintainer: Lukas D. Sauer <sauer@imbi.uni-heidelberg.de>
Description: Plan optimal sample size allocation and go/no-go decision
        rules for phase II/III drug development programs with
        time-to-event, binary or normally distributed endpoints when
        assuming fixed treatment effects or a prior distribution for
        the treatment effect, using methods from Kirchner et al. (2016)
        <doi:10.1002/sim.6624> and Preussler (2020). Optimal is in the
        sense of maximal expected utility, where the utility is a
        function taking into account the expected cost and benefit of
        the program. It is possible to extend to more complex settings
        with bias correction (Preussler S et al. (2020)
        <doi:10.1186/s12874-020-01093-w>), multiple phase III trials
        (Preussler et al. (2019) <doi:10.1002/bimj.201700241>),
        multi-arm trials (Preussler et al. (2019)
        <doi:10.1080/19466315.2019.1702092>), and multiple endpoints
        (Kieser et al. (2018) <doi:10.1002/pst.1861>).
License: MIT + file LICENSE
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.2
Depends: R (>= 3.5.0), doParallel, parallel, foreach, iterators
Imports: mvtnorm, cubature, msm, MASS, stats, progressr
URL: https://github.com/Sterniii3/drugdevelopR,
        https://sterniii3.github.io/drugdevelopR/
BugReports: https://github.com/Sterniii3/drugdevelopR/issues
Suggests: rmarkdown, knitr, testthat (>= 3.0.0), covr, kableExtra,
        magrittr, devtools
VignetteBuilder: knitr
Config/testthat/parallel: true
Config/testthat/edition: 3
Config/pak/sysreqs: make
Repository: https://sterniii3.r-universe.dev
Date/Publication: 2025-01-14 08:48:12 UTC
RemoteUrl: https://github.com/sterniii3/drugdevelopr
RemoteRef: HEAD
RemoteSha: dbead106b3edae4ac773c2d7e10f5937816db00a
NeedsCompilation: no
Packaged: 2026-07-03 20:22:30 UTC; root